Understanding the mechanisms that regulate nephron progenitors during kidney
development should aid development of therapies for renal failure. MicroRNAs, which
modulate gene expression through post-transcriptional repression of specific target mRNAs,
contribute to the differentiation of stem cells, but their role in nephrogenesis is incompletely
understood. Here, we found that the loss of miRNAs in nephron progenitors results in a
premature depletion of this population during kidney development. Increased apoptosis and …