An optimized method to visualize the goblet cell-associated antigen passages and identify goblet cells in the intestine, conjunctiva, and airway
M Tang, J Mei, M Sun, K Ma, A Zhao, X Fu - Immunobiology, 2022 - Elsevier
The goblet cell-associated antigen passages (GAPs), formed in the intestine and
conjunctiva, contribute to immune responses by delivering antigens to immune cells. It has
been proved that dysfunctions of GAPs may contribute to intestinal inflammation and dry eye
disease. GAPs were first discovered in the intestine with the help of intravital two-photon
microscopy. The imaging of GAPs was subsequently captured in a frozen section and whole-
mount immunofluorescent staining. Both protocols have their features. This study provides a …
conjunctiva, contribute to immune responses by delivering antigens to immune cells. It has
been proved that dysfunctions of GAPs may contribute to intestinal inflammation and dry eye
disease. GAPs were first discovered in the intestine with the help of intravital two-photon
microscopy. The imaging of GAPs was subsequently captured in a frozen section and whole-
mount immunofluorescent staining. Both protocols have their features. This study provides a …
