Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: one stone hits two birds
C Xu, X Wan, L Xu, H Weng, M Yan, M Miao, Y Sun… - Journal of …, 2015 - Elsevier
Background & Aims Hyperuricemia is a common feature of patients with non-alcoholic fatty
liver disease (NAFLD). This study aimed to explore the causal relationship and underlying
mechanisms between NAFLD and hyperuricemia. Methods We evaluated the impact of
NAFLD on the development of hyperuricemia in a cohort of 5541 baseline hyperuricemia-
free individuals. We further analyzed xanthine oxidase (XO), a rate-limiting enzyme that
catalyzes uric acid production, as a candidate to link NAFLD and hyperuricemia. Results In …
liver disease (NAFLD). This study aimed to explore the causal relationship and underlying
mechanisms between NAFLD and hyperuricemia. Methods We evaluated the impact of
NAFLD on the development of hyperuricemia in a cohort of 5541 baseline hyperuricemia-
free individuals. We further analyzed xanthine oxidase (XO), a rate-limiting enzyme that
catalyzes uric acid production, as a candidate to link NAFLD and hyperuricemia. Results In …
