[HTML][HTML] The impact of highly effective cystic fibrosis transmembrane conductance regulator modulators on the health of female subjects with cystic fibrosis
JL Taylor-Cousar, M Shteinberg… - Clinical Therapeutics, 2023 - Elsevier
Cystic fibrosis (CF) is a genetic disorder that occurs in people of all genetic ancestries. CF is
caused by variants in the CF transmembrane conductance regulator (CFTR) gene that result
in decreased, absent, or nonfunctional CFTR protein at the cell surface of the mucous
membranes. Clinical manifestations include chronic respiratory disease, malabsorption, and
decreased fertility. Historically, therapies for CF were focused on the signs and symptoms of
the disease. However, more recently, CFTR modulators, therapies directed at the basic …
caused by variants in the CF transmembrane conductance regulator (CFTR) gene that result
in decreased, absent, or nonfunctional CFTR protein at the cell surface of the mucous
membranes. Clinical manifestations include chronic respiratory disease, malabsorption, and
decreased fertility. Historically, therapies for CF were focused on the signs and symptoms of
the disease. However, more recently, CFTR modulators, therapies directed at the basic …
